Effects of Myocardial Edema on the Development of Myocardial Interstitial Fibrosis
Identifieur interne : 00A708 ( Main/Exploration ); précédent : 00A707; suivant : 00A709Effects of Myocardial Edema on the Development of Myocardial Interstitial Fibrosis
Auteurs : K. L. Davis [États-Unis] ; G. A. Laine [États-Unis] ; H. J. Geissler [Allemagne] ; U. Mehlhorn [Allemagne] ; M. Brennan [États-Unis] ; S. J. Allen [États-Unis]Source :
- Microcirculation [ 1073-9688 ] ; 2000-08.
Abstract
Objective: The mechanism by which chronic myocardial edema causes cardiac dysfunction is poorly understood. We hypothesized that myocardial edema triggers cardiac fibrosis development resulting in cardiac dysfunction. Since collagen is the most abundant constituent of the interstitial matrix, we examined the effects of edema development on cardiac collagen metabolism.
Url:
DOI: 10.1111/j.1549-8719.2000.tb00127.x
Affiliations:
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Allen</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Center for Microvascular and Lymphatic Studies, Department of Anesthesiology, The University of Texas‐Houston Medical School, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Microcirculation</title><title level="j" type="alt">MICROCIRCULATION</title><idno type="ISSN">1073-9688</idno><idno type="eISSN">1549-8719</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="269">269</biblScope><biblScope unit="page" to="280">280</biblScope><biblScope unit="page-count">12</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2000-08">2000-08</date></imprint><idno type="ISSN">1073-9688</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1073-9688</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Objective: The mechanism by which chronic myocardial edema causes cardiac dysfunction is poorly understood. 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